Exact Sciences Presents Advancements in Cancer Detection at American Association for Cancer Research® 2023 Annual Meeting

“Our data at AACR show notable progress across our pipeline of cancer tests, from screening to late-stage therapy selection,” said Jorge Garces, Ph.D., chief science officer, Exact Sciences. “The potential of MCED tests to detect many cancers from one blood draw is an incredible advancement for healthcare providers and their patients, and our data inform the optimal approach to identify where the cancer is located.”

Data presentations across Exact Sciences’ Screening and Precision Oncology portfolios at AACR 2023:

Poster #769: Evaluating the diagnostic burden of tumor localization strategies for multi-cancer early detection tests

Data embargoed until 1:30 p.m. ET on Sunday, April 16
Authors: Tyson, C, et al.
Date/Time: Sunday, April 16, 1:30 p.m. – 5:00 p.m. ET
Location: Section 28

Summary: In this analysis, advanced imaging identified the tissue of cancer origin following a positive MCED test resulting in fewer procedures to achieve cancer diagnosis when compared to molecular testing.

Poster #6694: Evaluation of a multi-omics approach to molecular residual disease detection 

Data embargoed until 9:00 a.m. ET on Wednesday, April 19
Authors: Culver B, et al.
Date/Time: Wednesday, April 19, 9:00 a.m. – 12:30 p.m. ET
Location: Section 40

Summary: MRD methodologies developed using variants specifically derived from the patient tumor (tumor-informed) and a pre-defined set of markers (tumor-agnostic) showed high concordance in cancer detection and complemented each other in differentiating cancer samples from non-cancer samples.

Poster #770: Provider communication contributes to colorectal cancer screening intention through improving screening outcome expectancies and perceived behavioral control

Data embargoed until 1:30 p.m. ET on Sunday, April 16
Authors: Zhu X, et al.
Date/Time: Sunday, April 16, 1:30 p.m. – 5:00 p.m. ET
Location: Section 28

Summary: Improving health care provider communication with patients regarding beliefs about the effectiveness and ease of use of multi-target stool DNA screening may contribute to colorectal screening completion.

Poster #2150: CLDN18/ARHGAP26 in gastric cancers

Data embargoed until 9:00 a.m. ET on Monday, April 17
Authors: Josefson D, et al.
Date/Time: Monday, April 17, 9:00 a.m. – 12:30 p.m. ET
Location: Section 39

Summary: OncoExTra™, an ultra-comprehensive DNA and RNA-based genomic test, was used to examine the prevalence of gastric cancer fusion CLDN18/ARHGAP26, that has been known to appear more often in young females and is associated with a poor prognosis and higher likelihood of metastasis.

About Exact Sciences Corp.
A leading provider of cancer screening and diagnostic tests, Exact Sciences relentlessly pursues smarter solutions providing the clarity to take life-changing action, earlier. Building on the success of Cologuard^® and Oncotype^® tests, Exact Sciences is investing in its product pipeline to support patients before and throughout their cancer diagnosis and treatment. Exact Sciences unites visionary collaborators to help advance the fight against cancer. For more information, please visit the company’s website at exactsciences.com, follow Exact Sciences on Twitter @ExactSciences, or find Exact Sciences on Facebook.

NOTE: OncoExTra, Oncotype, Oncotype DX, Oncotype DX Breast Recurrence Score, Oncotype DX Breast DCIS Score and Recurrence Score are trademarks or registered trademarks of Genomic Health, Inc. Exact Sciences and Cologuard are trademarks or registered trademarks of Exact Sciences Corporation. All other trademarks and service marks are the property of their respective owners.

Forward-Looking Statements

This news release contains forward-looking statements concerning our expectations, anticipations, intentions, beliefs or strategies regarding the future. These forward-looking statements are based on assumptions that we have made as of the date hereof and are subject to known and unknown risks and uncertainties that could cause actual results, conditions and events to differ materially from those anticipated. Therefore, you should not place undue reliance on forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding expected future operating results; our strategies, positioning, resources, capabilities and expectations for future events or performance; and the anticipated benefits of our acquisitions, including estimated synergies and other financial impacts.

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 References

[1] Tyson C, et al. Abstract #769, AACR 2023.

[2] Culver B, et al. Abstract #6694, AACR 2023.

[3] Zhu X, et al. Abstract #770, AACR 2023.

[4] Josefson D, et al. Abstract #2150, AACR 2023.

Contacts

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